Using Ketamine and Lexapro to Treat Treatment-Resistant Depression

Using Ketamine and Lexapro to Treat Treatment-Resistant Depression
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Using Ketamine and Lexapro to Treat Depression

Depression is a complex mental health disorder that affects millions of people globally. While there are many treatment options available, up to 30% of people living with depression do not respond adequately to first and second-line antidepressant medications like selective serotonin reuptake inhibitors (SSRIs) such as Lexapro (escitalopram).

However, exciting research in the last decade has shown that ketamine, a drug traditionally used for anesthesia, can be remarkably effective at rapidly reducing severe and treatment-resistant depression. When used alongside traditional antidepressants like Lexapro, ketamine is giving new hope to those living with stubborn, difficult-to-treat mental illness.

Limitations of Traditional Antidepressants

For many years, the first-line treatment for major depressive disorder has been SSRIs such as Lexapro (escitalopram). SSRIs work by increasing levels of serotonin in the brain, which is a neurotransmitter linked to mood regulation.

Unfortunately, lexapro and other SSRIs can take 4-6 weeks to take full effect. This means patients often have to wait over a month before experiencing relief from depressive symptoms. Even more problematic up to 30-40% of depressed patients see no benefits from antidepressant medications even after multiple trials. These patients suffer from stubborn, persisting depression that fails to respond to traditional treatment.

The Rise of Ketamine

In recent years, interest has spiked around using low doses of ketamine to rapidly treat severe, treatment-resistant depression.

Ketamine is a dissociative anesthetic agent that works very differently than standard antidepressants. It helps stimulate the growth of synapses and restore neural connections in areas of the brain that regulate mood, emotion and cognition.

What makes ketamine so revolutionary is it can rapidly reduce major depression in as little as 24 hours while standard antidepressants take 4-6 weeks to work. In addition, ketamine also has an incredible 70-85% response rate in patients who previously failed to see results from multiple antidepressant medications.

Ketamine and Lexapro Used Together

Currently, the most common protocol is to use ketamine alongside longer-term medications like Lexapro as part of a multi-pronged approach to treating depression. Heres why this combination approach is so effective:

  • Rapid relief Ketamine provides fast acting relief from depression symptoms when patients need it most.
  • Maintaining benefits Antidepressants like lexapro help sustain the mood boosting benefits unlocked by ketamine.
  • Fewer side effects Lower doses of both medications often leads to better tolerance vs. monotherapy.

Benefits of Using Ketamine for Depression Treatment

Study after study has shown incredible benefits associated with using ketamine for severe, stubborn depression including:

  1. Very rapid relief from depressive symptoms as little as 24 hours for some patients.
  2. Around 70-80% response rate in treatment resistant populations
  3. Fast reduction in thoughts about suicide
  4. Improvement in comorbid issues like anxiety
  5. Much better tolerability vs. ECT with few side effects
  6. Lasting recovery with as-needed maintenance dosing

Compare this to frustrating month+ long trial and response periods with traditional oral antidepressants and it is easy to see why excitement around ketamine treatment continues to build.

Is Ketamine Plus Lexapro Right for Me?

The combination of ketamine infusions plus daily Lexapro may be an excellent treatment path if you identify with any of the following:

  • Diagnosed with Major Depressive Disorder by a psychiatrist or doctor
  • Struggled to achieve remission from multiple antidepressant trials
  • Looking to rapidly improve severe depressive symptoms that are disrupting your life
  • Want to augment daily medication like Lexapro with a fast-acting therapeutic
  • Seeking hope after feeling like you have tried everything without success

Always consult your mental health professional before starting any new depression treatment. But millions of patients just like you are finding renewed hope and faster relief from blending ketamine and antidepressant medication.

Finding a Ketamine Clinic Near Me

Specialty mental health clinics offering ketamine infusions for depression treatment are expanding across North America and globally. To find a licensed center with certified psychiatrists near you:

  1. Ask your psychiatrist or primary care doctor for a referral
  2. Search online directory listings for ketamine therapy clinics
  3. Check out patient ratings and reviews of the clinic online
  4. Confirm the clinic uses licensed physicians (MD/DO credentials)
  5. Schedule a free consultation to learn more about the process

Reputable ketamine clinics will provide a full overview of their treatment process during a free call or visit. Be sure to ask about:

  • Their specific ketamine dosage protocols
  • What other antidepressants they recommend with ketamine
  • How they monitor patient safety and outcomes
  • What insurance plans they accept

With over a decade of clinical experience using ketamine to beat treatment-resistant depression, best practices continue to emerge. Finding an established clinic with proven results is key to achieving and maintaining mood benefits from this exciting new treatment option when standard medication has failed.

Achieving Long-Term Relief from Depression

For patients struggling with severe, difficult-to-treat depression, few innovations have been as promising as ketamine therapy. When combined with modern antidepressant medications like lexapro, ketamine is helping patients achieve fast relief from their symptoms often in days instead of months.

If you have any questions about using ketamine and lexapro together for your depression treatment, be sure to discuss candidly with your psychiatrist. Discover how this blended approach can help you find the fast-acting relief and lasting recovery you deserve.

FAQs

What are the side effects of ketamine infusions?

Common transient side effects of ketamine may include nausea, dizziness, blurred vision and dissociation. These effects typically dissipate within hours after treatment. Ketamine has a strong safety profile, especially at the low doses used for depression.

How quickly does ketamine work for depression?

Remarkably, ketamine has been shown to reduce major depression and suicidal thinking in as little as 24 hours. Effects typically peak within 2-3 days then taper off, hence the need for multiple/maintenance treatments.

Can I take Lexapro the day I have a ketamine infusion?

Yes, patients receiving ketamine therapy will concurrently take their daily antidepressant like Lexapro. It’s important not to adjust other mental health medications without first consulting your doctor or psychiatrist.

How many ketamine treatments will I need?

Clinical protocols call for 4-6 initial ketamine infusions spaced across 2-3 weeks to achieve remission, followed by maintenance dosing ranging every 1-3 months on an as-needed basis to prevent relapse.

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with a healthcare professional before starting any new treatment regimen.

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