How Long Can Semaglutide Stay Unrefrigerated Before Losing Potency?

Understanding Semaglutide Storage Requirements

Semaglutide is an injectable prescription medication used to improve blood sugar levels in adults with type 2 diabetes. It is sold under the brand names Ozempic and Wegovy. As with most medications, properly storing semaglutide is important to preserve its effectiveness.

One key storage requirement for semaglutide is refrigeration. Like many biological products, semaglutide starts breaking down when exposed to higher than recommended temperatures. So knowing how long it can safely stay unrefrigerated before losing efficacy is critical for proper use.

Fridge Temperature Guidelines

The manufacturer recommends storing unopened semaglutide between 36F to 46F (2C to 8C). The injector pens and bottles should be kept in the original carton until you are ready to use them to protect them from light.

Once opened, semaglutide can be stored out of the refrigerator at room temperature no higher than 86F (30C) for up to 4 weeks. Just make sure to discard semaglutide if it has been out of refrigeration for longer than a month.

Short-Term Heat Exposure

Brief short-term exposure to temperatures outside the recommended 36F to 46F (2C to 8C) fridge range will likely not damage semaglutide. As a general rule of thumb, Ozempic or Wegovy can safely remain out of refrigeration below 86F (30C) for up to 4 weeks.

So if your injector pen or bottle accidentally gets left out on the counter overnight or for a few hours during the day, it should be fine to put back in the fridge. Just try to minimize the frequency and duration of those unrefrigerated periods.

At Room Temperature and Above

Exposing semaglutide to room temperature or warmer for an extended period can start deteriorating the medication. In high heat above 86F (30C), the breakdown progresses faster.

The general guidance is to not use Ozempic or Wegovy if it has been stored out of refrigeration at room temperature for longer than 4 weeks. Be extra cautious if temperatures have exceeded 86F for over 48 hours.

Signs Semaglutide May Have Spoiled

When semaglutide loses potency from heat exposure, it typically does not show obvious visible signs. But here are a few clues your injector pen or bottle may have been too warm for too long:

• Cloudiness or discoloration in the normally clear and colorless medication
• Clumping or particles floating the solution
• An expired use by date stamped on the packaging

If you notice any of those, do not inject the medication. Properly dispose of it and get a new prescription from your doctor.

Maintaining Proper Semaglutide Storage

Following some key semaglutide storage best practices can help prevent waste from spoiled medication and ensure you get the full benefits:

Monitor Fridge Temperatures

Use a refrigerator thermometer to routinely check that your fridge is keeping semaglutide between 36F to 46F (2C to 8C). Make any needed adjustments to maintain temperatures in that ideal range.

Limit Heat Exposure

When traveling or commuting with semaglutide, use insulated bags or cooling packs to protect injector pens from getting too warm in hot environments. Never leave it sitting in direct sunlight or in a hot car.

Adhere to Expiration Dates

Check expiration dates on semaglutide packaging before injecting and do not use after that date. Also stick to the 4 week room temperature guidance for storage once opened.

Inspect Before Injecting

Always visually inspect semaglutide solution before injection. Look for any discoloration, cloudiness, particles or other signs it may have degraded from improper storage conditions.

Following semaglutide refrigeration guidelines ensures you get the full dose you need. A few simple habits like fridge temperature monitoring and heat protection prevent waste from spoiled medication.

If you have questions about proper storage, contact your pharmacist or the medication manufacturer. And report any issues like suspected spoiled product to the FDA at 1-800-FDA-1088.

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with a healthcare professional before starting any new treatment regimen.