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Understanding Semaglutide and Weight Loss

Semaglutide (brand names Ozempic and Wegovy) has recently gained popularity as a potential weight loss drug. It was originally approved as a treatment for type 2 diabetes, but studies have shown it also leads to significant weight loss in many patients. This has led to an increase in off-label use of semaglutide for weight management.

Semaglutide belongs to a class of drugs called GLP-1 receptor agonists. It mimics a hormone called glucagon-like peptide-1 (GLP-1) that is released naturally by the body after eating. GLP-1 slows digestion and suppresses appetite. Semaglutide works by activating GLP-1 receptors, which reduces appetite and food intake.

How Semaglutide Promotes Weight Loss

There are several ways semaglutide helps with weight loss:

• Suppresses appetite - Semaglutide activates areas of the brain that control food intake, making you feel fuller sooner and for longer.
• Delays gastric emptying - It slows down the rate at which food leaves your stomach, contributing to increased fullness and reduced appetite.
• Increases insulin production - This leads to better blood sugar control and can reduce fat storage.
• Improves satiety signals - Semaglutide enhances levels of satiety hormones like peptide YY and glucagon-like peptide-1.

Together, these effects make it easier to eat less, consume fewer calories, and lose weight. Studies show people taking semaglutide lose 5-15% of their body weight on average.

Who is a Candidate for Semaglutide?

Semaglutide is generally recommended for overweight or obese adults who have difficulty losing weight through diet and exercise alone. Ideal candidates include:

• People with a BMI 27 plus at least one weight-related health condition such as diabetes, hypertension, or heart disease.
• People with a BMI 30 with or without other health conditions.
• People who have tried other weight loss medications without success.

Semaglutide should not be used in those with a personal or family history of certain

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with a healthcare professional before starting any new treatment regimen.