Understanding Triple Negative Breast Cancer
Triple negative breast cancer (TNBC) is an aggressive type of breast cancer that accounts for 10-20% of all breast cancer cases. It tests negative for estrogen receptors, progesterone receptors, and excess HER2 protein, which means it does not respond to hormonal therapy medicines or medicines that target HER2 protein receptors. As a result, treatment options are more limited for TNBC compared to other types of breast cancer.
Characteristics of Triple Negative Breast Cancer
TNBC tends to be more common in:
- Younger women
- African American women
- Women with a BRCA1 gene mutation
It also often has these features:
- Grows and spreads faster than other types of breast cancer
- Has a higher chance of recurring after treatment
- Has a poorer prognosis compared to other breast cancers
Treatment of Triple Negative Breast Cancer
Because TNBC does not respond to hormonal therapy or HER2-targeted treatments, options include:
- Surgery
- Chemotherapy
- Radiation therapy
- Targeted therapy with PARP inhibitors for BRCA-related TNBC
- Immunotherapy clinical trials
The specific treatment plan depends on the stage of TNBC and whether or not it has spread to other parts of the body.
Spotlight on Triple Negative Breast Cancer Month
October is designated as National Breast Cancer Awareness Month. However, amidst all the pink ribbons and events, it's easy for certain breast cancer subtypes, like triple negative breast cancer (TNBC) to fall under the radar.
That's why advocates specifically promote October as Triple Negative Breast Cancer Month as well. The goal is to raise awareness about issues uniquely impacting those diagnosed with TNBC while also fundraising for specialized research and support services catering to this patient population.
Who Supports Triple Negative Breast Cancer Month
Several non-profit organizations champion Triple Negative Breast Cancer Month and provide valuable resources to those affected, including:
- Triple Negative Breast Cancer Foundation - Funds TNBC-specific research and provides education and support services.
- Tigerlily Foundation - Empowers young women before, during, and after breast cancer thru education, advocacy, research, and peer support.
- The Carey Foundation - Advances minority and underserved women’s access to breast cancer education, screening, treatment and support.
Ways to Get Involved
Everyone can make a meaningful difference during Triple Negative Breast Cancer Month by:
- Learning - Read up on TNBC signs, risks, treatment options, and survivorship issues.
- Spreading awareness - Share information with your friends and family.
- Supporting - Check in on loved ones touched by TNBC. Volunteer or fundraise for one of the TNBC-focused charities making an impact.
- Advocating - Contact government representatives urging them to prioritize policies ensuring affordable, equitable access to quality TNBC screening, diagnosis, care, and clinical trials.
TNBC Research Updates
There is also encouraging news on the TNBC research front. Recent and ongoing studies are revealing promising discoveries related to:
- Improved early detection blood tests
- Advancements in tumor profiling to match patients with tailored treatments
- Expanded immunotherapy clinical trials
- Novel targeted therapies and combination therapies
- Further clues into the role genetics and health disparities play in TNBC outcomes
Researchers and clinicians are optimistic this progress will steadily transform TNBC into a more treatable, controllable condition so those diagnosed have expanding possibilities for healing and long-term survival.
Conclusion
Triple negative breast cancer can be scary and disheartening due to its aggressiveness and limited treatment options. However, as spotlighted during TNBC Month every October, there is expanding hope on the horizon thanks to dedicated advocacy groups and researchers making this specific breast cancer subtype a priority.
By learning more about TNBC, promoting awareness, supporting those affected, advocating politically, and donating to reputable TNBC-focused charities, everyone can create meaningful positive change now while also helping accelerate breakthroughs for tomorrow.
FAQs
What is triple negative breast cancer (TNBC)?
Triple negative breast cancer is a subtype of breast cancer that tests negative for hormone receptors for estrogen and progesterone. It also does not overexpress the HER2 protein. This means TNBC does not respond to hormonal or HER2-targeted therapies, limiting treatment options.
How aggressive is triple negative breast cancer?
TNBC tends to grow and spread faster than some other breast cancer types. It also has higher chances of recurring after initial treatment and can have a poorer prognosis.
Who is at highest risk for triple negative breast cancer?
Risk factors for TNBC include being younger, African American, having a BRCA1 mutation, and having a family history of breast or ovarian cancer at a young age.
What is the best treatment for triple negative breast cancer?
Treatment options include surgery, several types of chemotherapy, radiation therapy, PARP inhibitors for BRCA-related TNBC, immunotherapy, and clinical trials investigating new targeted treatments.
What is the outlook for those with triple negative breast cancer?
Historically, TNBC has had worse outcomes than other breast cancer subtypes. However ongoing research shows promise of improving early detection, expanding treatment options, and eventually long-term control of triple negative breast cancer.
Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with a healthcare professional before starting any new treatment regimen.
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